ARPA-H FASTPASS · Technical Area 2 · DETECT

PELLUCID

Open-Vocabulary Spectral Intelligence for Through-Package Pharmaceutical Verification

Closed-set classifiers recognize known fakes. PELLUCID reads unknown chemistry — describing and quantifying never-catalogued adulterants through sealed packaging, in the language of chemistry itself.

RAMAN SHIFT 200–3200 cm⁻¹ · SIMULATED ACQUISITIONSENSOR-AGNOSTIC INGEST
The Problem

Every fielded screening system has a vocabulary ceiling

Today's detection asks one question: "is this one of the N substances I was trained on?" A counterfeiter only needs to be substance N+1. Novel adulterants are discovered in the market — after patients are harmed — not at the port of entry.

$528B
annual U.S. cost of drug-related morbidity & mortality (ARPA-H program materials)
150M+
Americans on medications touched by recalls each year
0.96
correlation score of glycerin + 20% diethylene glycol against pure reference — a passing grade
Glycerin adulterated with 20% diethylene glycol — the contaminant behind repeated mass-casualty poisonings — scores a 0.96 correlation against pure glycerin and "would pass as acceptable" under typical library thresholds. GREEN & BROWN, PHARMACEUTICAL TECHNOLOGY (2007) · THE DOCUMENTED FAILURE MODE OF CLOSED-SET MATCHING
The System

Four organs, one pipeline

Physics
THE LENS

Physics-informed neural inversion of light transport through real packaging — foil, blister, amber glass. Packaging is a causal intervention, not noise. Quantitative chemistry out.

Language
THE LEXICON

Recovered chemistry maps into a shared embedding with the written corpus of chemical knowledge. Describes never-catalogued adulterants — open-vocabulary description, not open-set rejection.

Adversary
THE FORGE

A generative counterfeit twin manufactures threats that don't exist yet and red-teams the system before fielding. A validation paradigm with no published prior art.

Decision
THE VERDICT

Calibrated risk, quantified uncertainty, plain-language narrative, spectral evidence trail — built for FDA auditability at port throughput.

Teaming · TA1 Partners

Sensor-agnostic by design

PELLUCID proposes into TA2 DETECT as a universal decoding layer: one intelligence stack that ingests Raman, NIR, hyperspectral, terahertz, photoacoustic, or fused streams — and makes every TA1 sensor's fielded accuracy, throughput, and regulatory story stronger. We are actively forming teams for the FASTPASS program.

"We bring the analytics. Your sensor is the star."

We are seeking
  • TA1 SAMPLE performers — any sensing modality — who want a decision-support layer purpose-built for their hardware
  • Academic partners in computational spectroscopy / chemometrics
  • Pharmaceutical analytical chemists for validation design
  • Access to reference spectral libraries and authentic / counterfeit sample sets
Start a teaming conversation

See it read unknown chemistry — live

The interactive walkthrough runs the full pipeline on sealed-shipment scenarios: acquisition through packaging, physics inversion, an open-vocabulary AI read, and a calibrated verdict certificate. The adversary loop invents a new counterfeit on demand and the system reads it anyway.

Open the demonstration →
Organization

Omega Wellness Center

Federal registration
UEI EMCBUDNAZKJ6 · CAGE 9BVW5 · SAM.gov active through 2027
Program
ARPA-H FASTPASS · Innovative Solutions Opening ARPA-H-SOL-26-160 · TA2 DETECT proposer
Intellectual property
PELLUCID IP owned and held by Omega Wellness Center; licensed for deployment across a portfolio of clinical and supply-chain platforms
Principal Investigator
Dr. Olalekan Joseph Olowe, DPT, MSc, MBA
Contact
joseph@josmolgroup.com · +1 915 478 8807 · El Paso, Texas
Core team
Jide Fadairo (CTO) · Dr. Chinwe Ogedegbe (CMO / Co-PI)